HPV Unit 3

Background Video

Target Course Objectives

List the 2 major oncoproteins and define/explain their functions/interactions as they relate to the disruption of the cell cycle and the cell cycle products

Unit Objectives

List the HPV Oncoproteins
Define the oncoproteins’ function and interaction with cell cycle proteins
Explain the Cell Cycle
- Define G1, G2, S, M phases
- Explain Cyclin function
- Explain CDK function
- Explain CDKI function
- Explain pRB function
- Explain p53 function
- Explain helicase Function
- Explain protesome function

Focus Questions

Let’s look at our patient’s scenario again:

A young woman, age 20, notices that she commonly has bleeding after sex with her boyfriend. She discovers that she has a raised area on her labia and seeks medical advice from a local Gynecologist. The woman has a Pap test performed and a small biopsy of the raised area on her labia. As she awaits her results, she seeks out information on the internet that fits her symptoms. Thinking about our patient presented in the overview section, how might her symptoms be explained by an HPV infection? Are there other entities that might contribute to the patient’s symptoms? What new information did you observe when watching the video again and how could it be helpful to include as an answer to our patient’s questions.

Reading Assignment

Watch HPV Life Cycle Video and review the life cycle of HPV as it pertains to the oncoproteins.
Review the material at the ASCCP’s site on the Natural History of HPV which explores the natural history of HPV infections including symptoms, causes, transmission and reducing risk of HPV infection.

Extra Tutorials

Watch the first 4:25 of the following video. The remainder of the video is about a detection method that will not be discussed in this mini course but is a part of Unit 4.
Review video tutorial HPV Cell Cycle for more detailed information on HPV oncoproteins’ effects on the cell cycle and cell transformation.

Unit 3 Quiz

Using a word document, submit your answers to the following questions:

How does the disruption of the cell cycle relate to our patient’s clinical presentation?
Do you think that the raised area on the labia is HPV related and why?
What do you expect this patient’s Pap test result to be and why?

Reflection and Discussion

Please use the Unit 3 discussion area to post your answers/word document. Comment on at least one of your classmate’s posts.

Mini Course Final Assessment

You will be divided into 5 groups of 3 students. Each group is responsible for creating a PowerPoint presentation or video that answers the questions the young woman in our patient scenario might have as she awaits her biopsy and Pap test results.
Please work within your assigned group to work on this presentation. I will assign you to your groups for this unit. You will need to select a leader for the group. The group leader will submit the first draft (due 3 days after unit begins) and final versions of your presentation (Due 5 days after unit begins).
Please make sure that the submitted presentation file name is formatted like the following: group no_last name_first name_title of presentation.
First Drafts will be posted to the discussion area for review by all groups and feedback on design and content will be provided by each student and by me.
You may save your work before submitting but please be aware that when you submit your final draft, it is final and you will not be allowed to edit it once submitted.
Final evaluations of this unit will be assessed by the HPV Presentation Rubric