HPV Unit 2
Background Video
Watch video about HPV Infection and think about how HPV could escape the immune system and could possibly explain out patient’s symptoms.
Target Course Objective
- List the 3 different coding regions of HPV DNA and describe the how they differ by identifying the viral proteins that each produces and when during the viral life cycle
Unit Objectives
- Define the HPV Genome:
- Early, Late and NCR coding regions and functions
- Define HPV Infection and Viral life cycle
- Labels the different Squamous mucosa layers
Focus Questions
Take 15 minutes and describe your understanding of the following focus questions:
- What are the differences between: Proteins vs. peptides vs. amino acids and what are each of their functions?
- Explain the process of DNA to protein synthesis and what role do you think this plays in the life cycle of HPV infections?
- Define the difference between CD4 and CD8 lymphocytes
- Explain the function and presentation of MHC Class I and II molecules and how this could relate to HPV escaping the immune response
- Explain Antigen/Antibody interactions
- Create a drawing of a cell with the following labels:
- Cell membrane
- Nucleus
- Endoplasmic reticulum
- Golgi apparatus
- Location of DNA
Reading Assignment
- Review the Reading Material on HPV. Think about how the HPV genome is organized and how HPV’s life cycle progresses through the different layers of the squamous epithelium.
- Watch HPV infection video and think about how HPV enters a normal cell and can integrate its DNA material into the human DNA.
- Review video tutorial HPV Genome & Infection to see how the normal cell growth effects the HPV life cycle along with HPV’s infectious cycle and the role of the human immune response to infection.
Unit 2 Quiz
- Label parts of squamous epithelium and define what is occurring in each layer as it relates to the HPV life cycle.
- Using a word document, define and describe how the immune system recognizes a cell that is infected with HPV DNA?
- Submit your answers to the discussion area.
Relfection and Discussion
Review answers and discuss with your classmates the concepts that you missed along with reflecting on the focusing questions from the unit. Please use the Unit 2 discussion area and use the following as guiding questions: What were some common mistakes you and your classmates made on the quiz? Which concepts were clarified during the unit and which do you still have questions?
Unit 2 Assessment
Complete the following quiz on presented materials for this unit: HPV Unit 2 Quiz
Carrying These Concepts Forward
Using a word document, Please answer the following question: HPV is thought to have a self limited infection cycle since the virus is released at the terminal end of the squamous layer. If no micro abrasion exists, why would some patients continue to have detectable HPV DNA? How could HPV be responsible for the raised area in our patient?